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Multidisciplinary Management of Orthopedic Patients With Sickle Cell Disease Sickle cell disease, an autosomal-recessive disorder, produces abnormal hemoglobin and erythrocytes, which leads to hemolytic anemia and microvascular occlusion. Patients with sickle cell disease often present with orthopedic disease manifestations requiring surgical intervention, with the most common indications being osteonecrosis and osteomyelitis. This article includes a systematic approach to the surgical management of patients with sickle cell disease. (full text) By Sathappan S. Sathappan, MD; Daniel Ginat, MD, MS; Paul E. Di Cesare, MD ORTHOPEDICS 2006; 29:1094
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